David Lagares Selected Research

N- methyl- N- (3- ((2- (2- oxo- 2,3- dihydro- 1H- indol- 5- ylamino)- 5- trifluoromethyl- pyrimidin- 4- ylamino)- methyl)- pyridin- 2- yl)- methanesulfonamide

12/2012	Adenoviral gene transfer of endothelin-1 in the lung induces pulmonary fibrosis through the activation of focal adhesion kinase.
5/2012	Inhibition of focal adhesion kinase prevents experimental lung fibrosis and myofibroblast formation.

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David Lagares Research Topics

Disease

23	Fibrosis (Cirrhosis) 12/2021 - 03/2010
6	Pulmonary Fibrosis (Fibrosing Alveolitis) 01/2021 - 12/2012
5	Cicatrix (Scar) 01/2020 - 03/2010
4	Neoplasms (Cancer) 01/2021 - 01/2008
4	Wounds and Injuries (Trauma) 01/2021 - 03/2010
3	Inflammation (Inflammations) 12/2021 - 01/2015
3	Lung Injury 12/2017 - 01/2016
2	Vascular Remodeling 12/2021 - 06/2011
2	Idiopathic Pulmonary Fibrosis 01/2020 - 10/2019
1	Hypoxia (Hypoxemia) 12/2021
1	Right Ventricular Dysfunction 12/2021
1	COVID-19 01/2021
1	Burns 01/2021
1	Infections 01/2021
1	Nematode Infections 01/2021
1	Pancreatic Neoplasms (Pancreatic Cancer) 01/2021
1	Systemic Scleroderma (Systemic Sclerosis) 01/2020
1	Hypotension (Low Blood Pressure) 01/2018
1	Autoimmune Diseases (Autoimmune Disease) 12/2017
1	Ureteral Obstruction 01/2017
1	Lung Diseases (Lung Disease) 01/2016
1	Hypertension (High Blood Pressure) 06/2011
1	Atherosclerosis 06/2011
1	Carcinogenesis 01/2008

Drug/Important Bio-Agent (IBA)

8	Bleomycin (Blenoxane)FDA LinkGeneric 01/2021 - 03/2010
4	Proteins (Proteins, Gene)FDA Link 01/2021 - 03/2010
3	CollagenIBA 01/2020 - 12/2012
3	Ephrin-B2 (Ephrin B2)IBA 12/2019 - 12/2017
3	Endothelin-1 (Endothelin 1)IBA 01/2015 - 03/2010
2	Metalloproteases (Metalloproteinases)IBA 01/2021 - 12/2017
2	DisintegrinsIBA 01/2021 - 12/2017
2	Extracellular Matrix ProteinsIBA 01/2021 - 01/2020
2	Transforming Growth Factor beta (TGF-beta)IBA 01/2021 - 01/2018
2	CytokinesIBA 01/2021 - 01/2020
2	EnzymesIBA 10/2019 - 01/2008
2	lysophosphatidic acidIBA 01/2016 - 01/2016
2	Bosentan (Tracleer)FDA Link 01/2015 - 03/2010
2	Vasoconstrictor AgentsIBA 01/2015 - 06/2011
2	Focal Adhesion Protein-Tyrosine KinasesIBA 12/2012 - 05/2012
2	N- methyl- N- (3- ((2- (2- oxo- 2,3- dihydro- 1H- indol- 5- ylamino)- 5- trifluoromethyl- pyrimidin- 4- ylamino)- methyl)- pyridin- 2- yl)- methanesulfonamideIBA 12/2012 - 05/2012
1	Matrix Metalloproteinase 1 (Interstitial Collagenase)IBA 12/2021
1	Matrix Metalloproteinases (MMPs)IBA 12/2021
1	Angiotensin-Converting Enzyme 2IBA 01/2021
1	Carbon Tetrachloride (Tetrachloromethane)IBA 01/2021
1	Membrane Proteins (Integral Membrane Proteins)IBA 01/2021
1	RNA (Ribonucleic Acid)IBA 01/2021
1	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 01/2021
1	FurinIBA 01/2021
1	Core Binding Factor Alpha 2 SubunitIBA 01/2021
1	SenotherapeuticsIBA 01/2020
1	Indicators and Reagents (Reagents)IBA 01/2020
1	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 01/2020
1	EphA1 Receptor (Eph Receptor)IBA 12/2019
1	LigandsIBA 12/2019
1	EphrinsIBA 12/2019
1	Eph Family Receptors (Eph Receptors)IBA 12/2019
1	Dopa DecarboxylaseIBA 10/2019
1	Dopamine Receptors (Dopamine Receptor)IBA 10/2019
1	Dopamine (Intropin)FDA LinkGeneric 10/2019
1	Aromatic-L-Amino-Acid DecarboxylasesIBA 10/2019
1	Transforming Growth Factors (Transforming Growth Factor)IBA 01/2019
1	Protein Isoforms (Isoforms)IBA 01/2018
1	Phosphotransferases (Kinase)IBA 01/2018
1	IntegrinsIBA 01/2018
1	rho-Associated KinasesIBA 01/2018
1	navitoclaxIBA 12/2017
1	Serum Response FactorIBA 01/2017
1	myocardinIBA 01/2017
1	Transcription Factors (Transcription Factor)IBA 01/2017
1	Type 2 Fibroblast Growth Factor Receptor (Fibroblast Growth Factor Receptor 2)IBA 01/2016
1	PAT-048IBA 01/2016
1	Pharmaceutical PreparationsIBA 01/2016
1	ErbB Receptors (EGF Receptor)IBA 01/2016
1	alkylglycerophosphoethanolamine phosphodiesteraseIBA 01/2016
1	Platelet-Derived Growth Factor Receptors (Platelet-Derived Growth Factor Receptor)IBA 01/2016
1	Lysophosphatidylcholines (Lysophosphatidylcholine)IBA 01/2016
1	Mutant Proteins (Protein, Mutant)IBA 02/2015
1	macitentanIBA 01/2015
1	2-methylcyclopentadienyl manganese tricarbonyl (MMT)IBA 01/2015
1	Peptides (Polypeptides)IBA 01/2015
1	Small Interfering RNA (siRNA)IBA 05/2012
1	Biological FactorsIBA 06/2011
1	Biological ProductsIBA 06/2011
1	Transforming Growth Factor beta1 (TGF beta 1)IBA 03/2010
1	4- (4- (3- (pyridin- 2- yl)- 1H- pyrazol- 4- yl)pyridin- 2- yl)- N- (tetrahydro- 2H- pyran- 4- yl)benzamideIBA 03/2010
1	Choline KinaseIBA 01/2008
1	Phospholipids (Phosphatides)FDA LinkGeneric 01/2008

Therapy/Procedure

6	Therapeutics 01/2020 - 01/2008
1	Ligation 01/2021
1	Radiotherapy 01/2021
1	Peritoneal Dialysis 01/2015